7SHI

Crystal Structure of Cytochrome P450 AmphL from Streptomyces nodosus and the Structural Basis for Substrate Selectivity in Macrolide Metabolizing P450s

Summary for 7SHI

Entry DOI	10.2210/pdb7shi/pdb
Descriptor	AmphL, PROTOPORPHYRIN IX CONTAINING FE, Amphotericin B, ... (5 entities in total)
Functional Keywords	amphotericin b, hydroxylase, p450, cytochrome, oxidoreductase
Biological source	Streptomyces nodosus
Total number of polymer chains	2
Total formula weight	89726.18
Authors	Amaya, J.A.,Poulos, T.L. (deposition date: 2021-10-08, release date: 2022-03-09, Last modification date: 2024-06-19)
Primary citation	Amaya, J.A.,Lamb, D.C.,Kelly, S.L.,Caffrey, P.,Murarka, V.C.,Poulos, T.L. Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s. J.Biol.Chem., 298:101746-101746, 2022 Cited by PubMed: 35189143 DOI: 10.1016/j.jbc.2022.101746 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation