7SHI

Crystal Structure of Cytochrome P450 AmphL from Streptomyces nodosus and the Structural Basis for Substrate Selectivity in Macrolide Metabolizing P450s

7SHI の概要

• エントリーDOI: 10.2210/pdb7shi/pdb
• 分子名称: AmphL, PROTOPORPHYRIN IX CONTAINING FE, Amphotericin B, ... (5 entities in total)
• 機能のキーワード: amphotericin b, hydroxylase, p450, cytochrome, oxidoreductase
• 由来する生物種: Streptomyces nodosus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89726.18

構造登録者

Amaya, J.A.,Poulos, T.L. (登録日: 2021-10-08, 公開日: 2022-03-09, 最終更新日: 2024-06-19)

• 主引用文献: Amaya, J.A.,Lamb, D.C.,Kelly, S.L.,Caffrey, P.,Murarka, V.C.,Poulos, T.L.; Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.; J.Biol.Chem., 298:101746-101746, 2022; PubMed: 35189143; DOI: 10.1016/j.jbc.2022.101746

実験手法

X-RAY DIFFRACTION (2 Å)