7SGJ
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with DKFZ-711
Summary for 7SGJ
Entry DOI | 10.2210/pdb7sgj/pdb |
Descriptor | Polyamine deacetylase HDAC10, 4-[(3-anilino-3-oxopropyl)(methyl)amino]-N-hydroxybutanamide, 1,2-ETHANEDIOL, ... (9 entities in total) |
Functional Keywords | histone deacetylase, hydrolase |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 1 |
Total formula weight | 75954.67 |
Authors | Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2021-10-05, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Steimbach, R.R.,Herbst-Gervasoni, C.J.,Lechner, S.,Stewart, T.M.,Klinke, G.,Ridinger, J.,Geraldy, M.N.E.,Tihanyi, G.,Foley, J.R.,Uhrig, U.,Kuster, B.,Poschet, G.,Casero Jr., R.A.,Medard, G.,Oehme, I.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144:18861-18875, 2022 Cited by PubMed: 36200994DOI: 10.1021/jacs.2c05030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)