7SF8
GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Summary for 7SF8
Entry DOI | 10.2210/pdb7sf8/pdb |
EMDB information | 25076 25077 |
Descriptor | Isoform 2 of Adhesion G-protein coupled receptor G1, G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (4 entities in total) |
Functional Keywords | adhesion gpcr, gpr56, adgrg1, tethered agonist, stalk, stachel, minig13, g13 heterotrimer, g protein, cryoem, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 106650.57 |
Authors | Barros-Alvarez, X.,Panova, O.,Skiniotis, G. (deposition date: 2021-10-03, release date: 2022-04-27, Last modification date: 2022-05-11) |
Primary citation | Barros-Alvarez, X.,Nwokonko, R.M.,Vizurraga, A.,Matzov, D.,He, F.,Papasergi-Scott, M.M.,Robertson, M.J.,Panova, O.,Yardeni, E.H.,Seven, A.B.,Kwarcinski, F.E.,Su, H.,Peroto, M.C.,Meyerowitz, J.G.,Shalev-Benami, M.,Tall, G.G.,Skiniotis, G. The tethered peptide activation mechanism of adhesion GPCRs. Nature, 604:757-762, 2022 Cited by PubMed: 35418682DOI: 10.1038/s41586-022-04575-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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