7SCE

Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor product PAP

7SCE の概要

• エントリーDOI: 10.2210/pdb7sce/pdb
• 分子名称: Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: sulfotransferase, heparan sulfate, oligosaccharide, complex, transferase, transferase-substrate complex, transferase/substrate
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44838.95

構造登録者

Wander, R.,Kaminski, A.M.,Krahn, J.M.,Liu, J.,Pedersen, L.C. (登録日: 2021-09-27, 公開日: 2022-01-19, 最終更新日: 2023-10-18)

• 主引用文献: Wander, R.,Kaminski, A.M.,Wang, Z.,Stancanelli, E.,Xu, Y.,Pagadala, V.,Li, J.,Krahn, J.M.,Pham, T.Q.,Liu, J.,Pedersen, L.C.; Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate; Acs Catalysis, 11:14956-14966, 2021; DOI: 10.1021/acscatal.1c04520

実験手法

X-RAY DIFFRACTION (2.75 Å)