7S8V

Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor

Summary for 7S8V

• Entry DOI: 10.2210/pdb7s8v/pdb
• EMDB information: 24791 24927
• Descriptor: Insulin-like growth factor 1 receptor, Insulin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: insulin receptor, type 1 insulin like growth factor receptor, hybrid receptor, insulin like growth factor i, leucine zipper, cryo electron microscopy, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 221288.24

Authors

Xu, Y.,Lawrence, M.C. (deposition date: 2021-09-20, release date: 2022-07-06, Last modification date: 2022-08-17)

• Primary citation: Xu, Y.,Margetts, M.B.,Venugopal, H.,Menting, J.G.,Kirk, N.S.,Croll, T.I.,Delaine, C.,Forbes, B.E.,Lawrence, M.C.; How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.; Structure, 30:1098-1108.e6, 2022; PubMed: 35660159; DOI: 10.1016/j.str.2022.05.007

Experimental method

ELECTRON MICROSCOPY (3.73 Å)