7S8V

Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor

7S8V の概要

• エントリーDOI: 10.2210/pdb7s8v/pdb
• EMDBエントリー: 24791 24927
• 分子名称: Insulin-like growth factor 1 receptor, Insulin receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: insulin receptor, type 1 insulin like growth factor receptor, hybrid receptor, insulin like growth factor i, leucine zipper, cryo electron microscopy, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 221288.24

構造登録者

Xu, Y.,Lawrence, M.C. (登録日: 2021-09-20, 公開日: 2022-07-06, 最終更新日: 2024-10-23)

主引用文献

Xu, Y.,Margetts, M.B.,Venugopal, H.,Menting, J.G.,Kirk, N.S.,Croll, T.I.,Delaine, C.,Forbes, B.E.,Lawrence, M.C.
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30:1098-1108.e6, 2022

PubMed Abstract: Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These hybrid receptors display ligand binding and signaling properties that differ from those of the homodimeric receptors. Here, we describe the cryoelectron microscopy structure of such a hybrid receptor in complex with insulin-like growth factor I (IGF-I). The structure (ca. 3.7 Å resolution) displays a single IGF-I ligand, bound in a similar fashion to that seen for IGFs in complex with IGF-1R. The IGF-I ligand engages the first leucine-rich-repeat domain and cysteine-rich region of the IGF-1R monomer (rather than those of the insulin receptor monomer), consistent with the determinants for IGF binding residing in the IGF-1R cysteine-rich region. The structure broadens our understanding of this receptor family and assists in delineating the key structural motifs involved in binding their respective ligands.

PubMed: 35660159
DOI: 10.1016/j.str.2022.05.007

実験手法

ELECTRON MICROSCOPY (3.73 Å)