7S84
Crystal structure of CDK2 liganded with compound TW8972
Summary for 7S84
Entry DOI | 10.2210/pdb7s84/pdb |
Descriptor | Cyclin-dependent kinase 2, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid (3 entities in total) |
Functional Keywords | allosteric inhibitor, drug development, kinase, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34324.81 |
Authors | Sun, L.,Schonbrunn, E. (deposition date: 2021-09-17, release date: 2022-09-28, Last modification date: 2023-10-25) |
Primary citation | Faber, E.B.,Sun, L.,Tang, J.,Roberts, E.,Ganeshkumar, S.,Wang, N.,Rasmussen, D.,Majumdar, A.,Hirsch, L.E.,John, K.,Yang, A.,Khalid, H.,Hawkinson, J.E.,Levinson, N.M.,Chennathukuzhi, V.,Harki, D.A.,Schonbrunn, E.,Georg, G.I. Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14:3213-3213, 2023 Cited by PubMed: 37270540DOI: 10.1038/s41467-023-38732-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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