7S7G

Crystal Structure Analysis of Human VLCAD

Summary for 7S7G

Entry DOI	10.2210/pdb7s7g/pdb
Descriptor	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	dehydrogenase, mitochondrial acyl-coa dehydrogenases, flavin adenine dinucleotide, deficiency, fatty acid oxidation, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	67611.99
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2021-09-15, release date: 2022-09-28, Last modification date: 2024-05-29)
Primary citation	Prew, M.S.,Camara, C.M.,Botzanowski, T.,Moroco, J.A.,Bloch, N.B.,Levy, H.R.,Seo, H.S.,Dhe-Paganon, S.,Bird, G.H.,Herce, H.D.,Gygi, M.A.,Escudero, S.,Wales, T.E.,Engen, J.R.,Walensky, L.D. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun, 13:3669-3669, 2022 Cited by PubMed: 35760926 DOI: 10.1038/s41467-022-31466-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.34 Å)

Structure validation