7S3X

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-(((pyridin-2-ylmethyl)amino)methyl)phenoxy)methyl)quinolin-2-amine

Summary for 7S3X

Entry DOI	10.2210/pdb7s3x/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	nitric oxide synthase inhibitor, heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	100268.95
Authors	Li, H.,Poulos, T.L. (deposition date: 2021-09-08, release date: 2022-09-14, Last modification date: 2023-10-18)
Primary citation	Lewis, M.C.,Weerawarna, P.M.,Li, H.,Murarka, V.,Silverman, R.B.,Poulos, T.L. Selective anti-MRSA inhibitors targetting bacterial nitric oxide synthase To be published,
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation