7S3J

Crystal Structure of AspB P450 in complex with brevianamide F substrates

7S3J の概要

• エントリーDOI: 10.2210/pdb7s3j/pdb
• 分子名称: AspB, PROTOPORPHYRIN IX CONTAINING FE, (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, ... (5 entities in total)
• 機能のキーワード: cytochrome p450, natural products, diketopiperazine, dimerase, biosynthetic protein
• 由来する生物種: Streptomyces sp. NRRL S-1868
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90011.41

構造登録者

Newmister, S.A.,Shende, V.V.,Harris, N.R.,Sanders, J.N.,Khatri, Y.,Movassaghi, M.,Houk, K.N.,Sherman, D.H. (登録日: 2021-09-07, 公開日: 2022-11-09, 最終更新日: 2023-10-25)

• 主引用文献: Shende, V.V.,Harris, N.R.,Sanders, J.N.,Newmister, S.A.,Khatri, Y.,Movassaghi, M.,Houk, K.N.,Sherman, D.H.; Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases.; Angew.Chem.Int.Ed.Engl., 62:e202210254-e202210254, 2023; PubMed: 36610039; DOI: 10.1002/anie.202210254

実験手法

X-RAY DIFFRACTION (1.94 Å)