7S3F

Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its inhibitor 1-amino-oxy-3-aminopropane

Summary for 7S3F

• Entry DOI: 10.2210/pdb7s3f/pdb
• Descriptor: Ornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, 3-AMINOOXY-1-AMINOPROPANE, ... (4 entities in total)
• Functional Keywords: pyridoxal 5-phosphate, human ornithine decarboxylase, inhibitor, 1-amino-oxy-3-aminopropane, lyase, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 95157.76

Authors

Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K. (deposition date: 2021-09-06, release date: 2021-12-15, Last modification date: 2023-10-18)

• Primary citation: Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K.; Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.; Biochem.J., 478:4137-4149, 2021; PubMed: 34796899; DOI: 10.1042/BCJ20210647

Experimental method

X-RAY DIFFRACTION (2.49 Å)