7S3F
Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its inhibitor 1-amino-oxy-3-aminopropane
Summary for 7S3F
Entry DOI | 10.2210/pdb7s3f/pdb |
Descriptor | Ornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, 3-AMINOOXY-1-AMINOPROPANE, ... (4 entities in total) |
Functional Keywords | pyridoxal 5-phosphate, human ornithine decarboxylase, inhibitor, 1-amino-oxy-3-aminopropane, lyase, lyase-inhibitor complex, lyase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 95157.76 |
Authors | Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K. (deposition date: 2021-09-06, release date: 2021-12-15, Last modification date: 2023-10-18) |
Primary citation | Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K. Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane. Biochem.J., 478:4137-4149, 2021 Cited by PubMed: 34796899DOI: 10.1042/BCJ20210647 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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