7S3F

Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with its inhibitor 1-amino-oxy-3-aminopropane

7S3F の概要

• エントリーDOI: 10.2210/pdb7s3f/pdb
• 分子名称: Ornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, 3-AMINOOXY-1-AMINOPROPANE, ... (4 entities in total)
• 機能のキーワード: pyridoxal 5-phosphate, human ornithine decarboxylase, inhibitor, 1-amino-oxy-3-aminopropane, lyase, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95157.76

構造登録者

Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K. (登録日: 2021-09-06, 公開日: 2021-12-15, 最終更新日: 2023-10-18)

• 主引用文献: Zhou, X.E.,Suino-Powell, K.,Schultz, C.R.,Aleiwi, B.,Brunzelle, J.S.,Lamp, J.,Vega, I.E.,Ellsworth, E.,Bachmann, A.S.,Melcher, K.; Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.; Biochem.J., 478:4137-4149, 2021; PubMed: 34796899; DOI: 10.1042/BCJ20210647

実験手法

X-RAY DIFFRACTION (2.49 Å)