7S1B

Crystal structure of Epstein-Barr virus glycoproteins gH/gL/gp42-peptide in complex with human neutralizing antibodies 769C2 and 770F7

7S1B の概要

• エントリーDOI: 10.2210/pdb7s1b/pdb
• 分子名称: Envelope glycoprotein H, Envelope glycoprotein L, 770F7 Fab heavy chain, ... (8 entities in total)
• 機能のキーワード: antibody, fab, immune system, gh/gl, epstein-barr virus, herpesvirus
• 由来する生物種: Human gammaherpesvirus 4 (Epstein-Barr virus); 詳細
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 184639.97

構造登録者

Chen, W.-H.,Cohen, J.I.,Kanekiyo, M.,Joyce, M.G. (登録日: 2021-09-02, 公開日: 2022-11-09, 最終更新日: 2023-10-18)

• 主引用文献: Chen, W.H.,Kim, J.,Bu, W.,Board, N.L.,Tsybovsky, Y.,Wang, Y.,Hostal, A.,Andrews, S.F.,Gillespie, R.A.,Choe, M.,Stephens, T.,Yang, E.S.,Pegu, A.,Peterson, C.E.,Fisher, B.E.,Mascola, J.R.,Pittaluga, S.,McDermott, A.B.,Kanekiyo, M.,Joyce, M.G.,Cohen, J.I.; Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition.; Immunity, 55:2135-2148.e6, 2022; PubMed: 36306784; DOI: 10.1016/j.immuni.2022.10.003

実験手法

X-RAY DIFFRACTION (3.03 Å)