7RYV

Anti-HIV neutralizing antibody Ab1573 Fab isolated from sequentially immunized macaques

Summary for 7RYV

• Entry DOI: 10.2210/pdb7ryv/pdb
• Descriptor: Ab1573 Fab heavy chain, Ab1573 Fab light chain (3 entities in total)
• Functional Keywords: anti-hiv antibody; neutralizing antibody; immunogen design, immune system
• Biological source: Macaca mulatta (Rhesus monkey); More
• Total number of polymer chains: 8
• Total formula weight: 189066.78

Authors

Yang, Z.,Bjorkman, P.J. (deposition date: 2021-08-26, release date: 2022-01-19, Last modification date: 2023-10-18)

• Primary citation: Yang, Z.,Dam, K.A.,Bridges, M.D.,Hoffmann, M.A.G.,DeLaitsch, A.T.,Gristick, H.B.,Escolano, A.,Gautam, R.,Martin, M.A.,Nussenzweig, M.C.,Hubbell, W.L.,Bjorkman, P.J.; Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.; Nat Commun, 13:732-732, 2022; PubMed: 35136084; DOI: 10.1038/s41467-022-28424-3

Experimental method

X-RAY DIFFRACTION (2.5 Å)