7RXU

Crystal structure of Cj1090c

Summary for 7RXU

• Entry DOI: 10.2210/pdb7rxu/pdb
• Descriptor: Lipoprotein, GLYCEROL, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bacterial lipoprotein, lps, lpte, outer membrane, transport protein
• Biological source: Campylobacter jejuni
• Total number of polymer chains: 1
• Total formula weight: 17529.76

Authors

Kim, Y.,Yeo, H.J. (deposition date: 2021-08-23, release date: 2022-08-31, Last modification date: 2024-05-22)

Primary citation

Paek, S.,Kawai, F.,Venisetty, N.,Kim, Y.,Yeo, H.J.
Crystal structure of Campylobacter jejuni lipoprotein Cj1090c.
Proteins, 91:293-299, 2023

PubMed Abstract: In Gram-negative bacteria, lipopolysaccharide (LPS) is an essential component of the asymmetric outer membrane (OM). LptE is an OM lipoprotein that forms a complex with the β-barrel OM protein, LptD. Incorporation of LPS into the OM outer leaflet is essential for bacterial viability, and mediated by the LptD/E complex. The genome of Campylobacter jejuni, a major foodborne pathogen, contains over 20 putative lipoproteins including Cj1090c. Here, we report the crystal structure of Cj1090c at 2.4 Å resolution, revealing structural evidence for LptE in C. jejuni. The analysis of this crystal structure, along with the genomic context, allows us to propose the C. jejuni LPS transport system for the first time, and permits for discussion of the features of the LptD/E complex of C. jejuni.

PubMed: 36201627
DOI: 10.1002/prot.26434

Experimental method

X-RAY DIFFRACTION (2.4 Å)