7RWN

Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one

7RWN の概要

• エントリーDOI: 10.2210/pdb7rwn/pdb
• 分子名称: Nucleosome-remodeling factor subunit BPTF, 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: brd4, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15763.25

構造登録者

Zahid, H.,Buchholz, C.,Johnson, J.A.,Shi, K.,Aihara, H.,Pomerantz, W.C.K. (登録日: 2021-08-20, 公開日: 2022-08-24, 最終更新日: 2023-10-18)

• 主引用文献: Zahid, H.,Buchholz, C.R.,Singh, M.,Ciccone, M.F.,Chan, A.,Nithianantham, S.,Shi, K.,Aihara, H.,Fischer, M.,Schonbrunn, E.,Dos Santos, C.O.,Landry, J.W.,Pomerantz, W.C.K.; New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.; J.Med.Chem., 64:13902-13917, 2021; PubMed: 34515477; DOI: 10.1021/acs.jmedchem.1c01294

実験手法

X-RAY DIFFRACTION (1.39 Å)