7RUE

DAHP synthase complexed with trifluoropyruvate semicarbazone

Summary for 7RUE

Entry DOI	10.2210/pdb7rue/pdb
Descriptor	Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, (2E)-2-(2-carbamoylhydrazinylidene)-3,3,3-trifluoropropanoic acid, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	dahp synthase, inhibitor complex, lyase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	4
Total formula weight	153482.32
Authors	Heimhalt, M.,Mukherjee, P.,Grainger, R.,Szabla, R.,Brown, C.,Turner, R.,Junop, M.S.,Berti, P.J. (deposition date: 2021-08-16, release date: 2021-11-17, Last modification date: 2023-10-18)
Primary citation	Heimhalt, M.,Mukherjee, P.,Grainger, R.A.,Szabla, R.,Brown, C.,Turner, R.,Junop, M.S.,Berti, P.J. An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition. Acs Infect Dis., 7:3292-3302, 2021 Cited by PubMed: 34761906 DOI: 10.1021/acsinfecdis.1c00462 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation