7RUD

DAHP synthase complex with trifluoropyruvate oxime

7RUD の概要

• エントリーDOI: 10.2210/pdb7rud/pdb
• 分子名称: Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, (2Z)-3,3,3-trifluoro-2-(hydroxyimino)propanoic acid (3 entities in total)
• 機能のキーワード: dahp synthase, inhibitor, complex, lyase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 152937.36

構造登録者

Heimhalt, M.,Mukherjee, P.,Grainger, R.,Szabla, R.,Brown, C.,Turner, R.,Junop, M.S.,Berti, P.J. (登録日: 2021-08-16, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Heimhalt, M.,Mukherjee, P.,Grainger, R.A.,Szabla, R.,Brown, C.,Turner, R.,Junop, M.S.,Berti, P.J.; An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition.; Acs Infect Dis., 7:3292-3302, 2021; PubMed: 34761906; DOI: 10.1021/acsinfecdis.1c00462

実験手法

X-RAY DIFFRACTION (2.8 Å)