7RTP

Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea]

7RTP の概要

• エントリーDOI: 10.2210/pdb7rtp/pdb
• 分子名称: JTO light chain, PHOSPHATE ION, N-{2-[7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]ethyl}-N'-[(pyridin-3-yl)methyl]urea, ... (4 entities in total)
• 機能のキーワード: amyloidosis, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47021.52

構造登録者

Yan, N.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2021-08-13, 公開日: 2022-02-16, 最終更新日: 2023-10-18)

• 主引用文献: Yan, N.L.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Morgan, G.J.,Kelly, J.W.; Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.; Bioorg.Med.Chem.Lett., 60:128571-128571, 2022; PubMed: 35065233; DOI: 10.1016/j.bmcl.2022.128571

実験手法

X-RAY DIFFRACTION (2.09 Å)