7RTC

Crystal structure of the ARM domain from Drosophila SARM1 in complex with NaMN

Summary for 7RTC

• Entry DOI: 10.2210/pdb7rtc/pdb
• Descriptor: NAD(+) hydrolase sarm1, NICOTINATE MONONUCLEOTIDE (2 entities in total)
• Functional Keywords: axon degeneration, arm domain, inhibitor, hydrolase
• Biological source: Drosophila melanogaster (Fruit fly)
• Total number of polymer chains: 3
• Total formula weight: 121418.55

Authors

Gu, W.,Ve, T.,Kobe, B. (deposition date: 2021-08-13, release date: 2021-09-01, Last modification date: 2023-10-18)

• Primary citation: Sasaki, Y.,Zhu, J.,Shi, Y.,Gu, W.,Kobe, B.,Ve, T.,DiAntonio, A.,Milbrandt, J.; Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection.; Exp Neurol, 345:113842-113842, 2021; PubMed: 34403688; DOI: 10.1016/j.expneurol.2021.113842

Experimental method

X-RAY DIFFRACTION (3.31 Å)