7RSC
NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc
Summary for 7RSC
Entry DOI | 10.2210/pdb7rsc/pdb |
NMR Information | BMRB: 30734 |
Descriptor | GTPase KRas, Apolipoprotein A-I, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ... (6 entities in total) |
Functional Keywords | nanodisc, oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 189151.73 |
Authors | Lee, K.,Enomoto, M.,Gebregiworgis, T.,Gasmi-Seabrook, G.M.,Ikura, M.,Marshall, C.B. (deposition date: 2021-08-11, release date: 2021-09-22, Last modification date: 2024-05-15) |
Primary citation | Lee, K.Y.,Enomoto, M.,Gebregiworgis, T.,Gasmi-Seabrook, G.M.C.,Ikura, M.,Marshall, C.B. Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12:12827-12837, 2021 Cited by PubMed: 34703570DOI: 10.1039/d1sc03484g PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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