7RRD
IDO1 IN COMPLEX WITH COMPOUND S-1
Summary for 7RRD
Entry DOI | 10.2210/pdb7rrd/pdb |
Descriptor | Indoleamine 2,3-dioxygenase 1, 3-[4-(1H-benzimidazol-2-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide (3 entities in total) |
Functional Keywords | indoleamine dioxygenase, heme, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 89485.02 |
Authors | |
Primary citation | Li, D.,Sloman, D.,Achab, A.,Zhou, H.,McGowan, M.,White, C.,Gibeau, C.,Zhang, H.,Pu, Q.,Bharathan, I.,Hopkins, B.,Liu, K.,Ferguson, H.,Fradera, X.,Lesburg, C.A.,Martinot, T.A.,Qi, J.,Song, Z.J.,Yin, J.,Song, L.,Wan, B.,D'Addio, S.,Solban, N.,Miller, R.,Zamlynny, B.,Bass, A.,Freeland, E.,Ykoruk, B.,Hilliard, C.,Ferraro, J.,Zhai, J.,Knemayer, I.,Otte, K.,Vincent, S.,Sciammetta, N.,Pasternak, A.,Bennett, D.J.,Han, Y. Oxetane promise delivered: discovery of long acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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