7RRD

IDO1 IN COMPLEX WITH COMPOUND S-1

7RRD の概要

• エントリーDOI: 10.2210/pdb7rrd/pdb
• 分子名称: Indoleamine 2,3-dioxygenase 1, 3-[4-(1H-benzimidazol-2-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide (3 entities in total)
• 機能のキーワード: indoleamine dioxygenase, heme, inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 89485.02

構造登録者

Lesburg, C.A. (登録日: 2021-08-09, 公開日: 2022-08-24, 最終更新日: 2024-10-16)

• 主引用文献: Li, D.,Sloman, D.,Achab, A.,Zhou, H.,McGowan, M.,White, C.,Gibeau, C.,Zhang, H.,Pu, Q.,Bharathan, I.,Hopkins, B.,Liu, K.,Ferguson, H.,Fradera, X.,Lesburg, C.A.,Martinot, T.A.,Qi, J.,Song, Z.J.,Yin, J.,Song, L.,Wan, B.,D'Addio, S.,Solban, N.,Miller, R.,Zamlynny, B.,Bass, A.,Freeland, E.,Ykoruk, B.,Hilliard, C.,Ferraro, J.,Zhai, J.,Knemayer, I.,Otte, K.,Vincent, S.,Sciammetta, N.,Pasternak, A.,Bennett, D.J.,Han, Y.; Oxetane promise delivered: discovery of long acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing; To Be Published,

実験手法

X-RAY DIFFRACTION (2.76 Å)