7RPE
X-ray crystal structure of OXA-24/40 in complex with ertapenem
Summary for 7RPE
Entry DOI | 10.2210/pdb7rpe/pdb |
Descriptor | Beta-lactamase, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | acyl-enzyme complex, carbapenemase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Acinetobacter baumannii |
Total number of polymer chains | 1 |
Total formula weight | 28448.53 |
Authors | Powers, R.A.,Mitchell, J.M.,June, C.M. (deposition date: 2021-08-03, release date: 2022-07-06, Last modification date: 2023-11-15) |
Primary citation | Mitchell, J.M.,June, C.M.,Baggett, V.L.,Lowe, B.C.,Ruble, J.F.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A. Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298:102127-102127, 2022 Cited by PubMed: 35709986DOI: 10.1016/j.jbc.2022.102127 PDB entries with the same primary citation |
Experimental method |
Structure validation
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