7RPE

X-ray crystal structure of OXA-24/40 in complex with ertapenem

7RPE の概要

• エントリーDOI: 10.2210/pdb7rpe/pdb
• 分子名称: Beta-lactamase, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: acyl-enzyme complex, carbapenemase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28448.53

構造登録者

Powers, R.A.,Mitchell, J.M.,June, C.M. (登録日: 2021-08-03, 公開日: 2022-07-06, 最終更新日: 2023-11-15)

• 主引用文献: Mitchell, J.M.,June, C.M.,Baggett, V.L.,Lowe, B.C.,Ruble, J.F.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A.; Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40.; J.Biol.Chem., 298:102127-102127, 2022; PubMed: 35709986; DOI: 10.1016/j.jbc.2022.102127

実験手法

X-RAY DIFFRACTION (1.53 Å)