7RNY

Carbonic Anhydrase II in complex with 3-ureido benzenesulfonamide derivative

Summary for 7RNY

Entry DOI	10.2210/pdb7rny/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 3-{[benzyl(methyl)carbamoyl]amino}benzene-1-sulfonamide, ... (5 entities in total)
Functional Keywords	glaucoma, ca, inhibitor, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29765.94
Authors	Combs, J.,McKenna, R. (deposition date: 2021-07-30, release date: 2022-06-08, Last modification date: 2023-10-18)
Primary citation	Vannozzi, G.,Vullo, D.,Angeli, A.,Ferraroni, M.,Combs, J.,Lomelino, C.,Andring, J.,Mckenna, R.,Bartolucci, G.,Pallecchi, M.,Lucarini, L.,Sgambellone, S.,Masini, E.,Carta, F.,Supuran, C.T. One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. J.Med.Chem., 65:824-837, 2022 Cited by PubMed: 34958217 DOI: 10.1021/acs.jmedchem.1c01906 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation