7RNY

Carbonic Anhydrase II in complex with 3-ureido benzenesulfonamide derivative

7RNY の概要

• エントリーDOI: 10.2210/pdb7rny/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 3-{[benzyl(methyl)carbamoyl]amino}benzene-1-sulfonamide, ... (5 entities in total)
• 機能のキーワード: glaucoma, ca, inhibitor, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29765.94

構造登録者

Combs, J.,McKenna, R. (登録日: 2021-07-30, 公開日: 2022-06-08, 最終更新日: 2023-10-18)

• 主引用文献: Vannozzi, G.,Vullo, D.,Angeli, A.,Ferraroni, M.,Combs, J.,Lomelino, C.,Andring, J.,Mckenna, R.,Bartolucci, G.,Pallecchi, M.,Lucarini, L.,Sgambellone, S.,Masini, E.,Carta, F.,Supuran, C.T.; One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.; J.Med.Chem., 65:824-837, 2022; PubMed: 34958217; DOI: 10.1021/acs.jmedchem.1c01906

実験手法

X-RAY DIFFRACTION (1.29 Å)