7RNJ

S2P6 Fab fragment bound to the SARS-CoV/SARS-CoV-2 spike stem helix peptide

Summary for 7RNJ

• Entry DOI: 10.2210/pdb7rnj/pdb
• Descriptor: Monoclonal antibody S2P6 Fab light chain, Monoclonal antibody S2P6 Fab heavy chain, Spike glycoprotein stem helix peptide, ... (5 entities in total)
• Functional Keywords: covid-19, sars-cov-2, neutralizing monoclonal antibody, viral protein-immune system complex, antiviral protein, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 49439.05

Authors

Snell, G.,Czudnochowski, N.,Croll, T.I.,Nix, J.C.,Corti, D.,Cameroni, E.,Pinto, D.,Beltramello, M.,Sauer, M.M.,Veesler, D. (deposition date: 2021-07-29, release date: 2021-08-11, Last modification date: 2024-04-03)

• Primary citation: Pinto, D.,Sauer, M.M.,Czudnochowski, N.,Low, J.S.,Tortorici, M.A.,Housley, M.P.,Noack, J.,Walls, A.C.,Bowen, J.E.,Guarino, B.,Rosen, L.E.,di Iulio, J.,Jerak, J.,Kaiser, H.,Islam, S.,Jaconi, S.,Sprugasci, N.,Culap, K.,Abdelnabi, R.,Foo, C.,Coelmont, L.,Bartha, I.,Bianchi, S.,Silacci-Fregni, C.,Bassi, J.,Marzi, R.,Vetti, E.,Cassotta, A.,Ceschi, A.,Ferrari, P.,Cippa, P.E.,Giannini, O.,Ceruti, S.,Garzoni, C.,Riva, A.,Benigni, F.,Cameroni, E.,Piccoli, L.,Pizzuto, M.S.,Smithey, M.,Hong, D.,Telenti, A.,Lempp, F.A.,Neyts, J.,Havenar-Daughton, C.,Lanzavecchia, A.,Sallusto, F.,Snell, G.,Virgin, H.W.,Beltramello, M.,Corti, D.,Veesler, D.; Broad betacoronavirus neutralization by a stem helix-specific human antibody.; Science, 373:1109-1116, 2021; PubMed: 34344823; DOI: 10.1126/science.abj3321

Experimental method

X-RAY DIFFRACTION (2.67 Å)