7RLR

Crystal Structure of K83A Mutant of Class D beta-lactamase from Clostridium difficile 630

7RLR の概要

• エントリーDOI: 10.2210/pdb7rlr/pdb
• 分子名称: Beta-lactamase, CHLORIDE ION, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, blad, hydrolase
• 由来する生物種: Clostridioides difficile (Peptoclostridium difficile)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 117458.95

構造登録者

Minasov, G.,Shuvalova, L.,Dubrovska, I.,Rosas-Lemus, M.,Jedrzejczak, R.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2021-07-26, 公開日: 2021-08-11, 最終更新日: 2026-02-11)

主引用文献

Rosas-Lemus, M.,Dey, S.,Minasov, G.,Tan, K.,Anderson, S.M.,Brunzelle, J.,Nocadello, S.,Shabalin, I.,Filippova, E.,Halavaty, A.,Kim, Y.,Maltseva, N.,Osipiuk, J.,Minor, W.,Joachimiak, A.,Savchenko, A.,Anderson, W.F.,Satchell, K.J.F.
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile.
Microbiol Resour Announc, 12:e0050723-e0050723, 2023

PubMed Abstract: causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

PubMed: 37747257
DOI: 10.1128/MRA.00507-23

実験手法

X-RAY DIFFRACTION (1.88 Å)