7RLF
Cryo-EM structure of human p97-E470D mutant bound to ATPgS.
Summary for 7RLF
Entry DOI | 10.2210/pdb7rlf/pdb |
EMDB information | 24528 |
Descriptor | Transitional endoplasmic reticulum ATPase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION (3 entities in total) |
Functional Keywords | p97, vcp, tera, inhibitor, cb-5083, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 543107.36 |
Authors | Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. (deposition date: 2021-07-23, release date: 2021-09-22, Last modification date: 2024-06-05) |
Primary citation | Caffrey, B.,Zhu, X.,Berezuk, A.,Tuttle, K.,Chittori, S.,Subramaniam, S. AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. J.Biol.Chem., 297:101187-101187, 2021 Cited by PubMed: 34520757DOI: 10.1016/j.jbc.2021.101187 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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