7RKE

Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-(((2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methyl)phenol and GRIP Peptide

7RKE の概要

• エントリーDOI: 10.2210/pdb7rke/pdb
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, 4-{[(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methyl}phenol, ... (4 entities in total)
• 機能のキーワード: estrogen receptor, breast cancer, agonist, partial agonist, alpha helical bundle, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 60169.69

構造登録者

Joiner, C.,Sammeta, V.K.R.,Norris, J.D.,McDonnell, D.P.,Willson, T.M.,Fanning, S.W. (登録日: 2021-07-22, 公開日: 2022-06-22, 最終更新日: 2023-10-18)

• 主引用文献: Sammeta, V.R.,Norris, J.D.,Artham, S.,Torrice, C.D.,Byemerwa, J.,Joiner, C.,Fanning, S.W.,McDonnell, D.P.,Willson, T.M.; A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core.; Acs Med.Chem.Lett., 13:1151-1158, 2022; PubMed: 35859859; DOI: 10.1021/acsmedchemlett.2c00180

実験手法

X-RAY DIFFRACTION (1.55 Å)