7RGY

Crystal structure of human galectin-3 CRD in complex with Methyl 2-O-(2-nitro-4-chloro)-benzoyl-3-O-toluoyl-b-D-talopyranoside

7RGY の概要

• エントリーDOI: 10.2210/pdb7rgy/pdb
• 分子名称: Galectin-3, CHLORIDE ION, methyl 2-O-(4-chloro-2-nitrobenzoyl)-3-O-(4-methylbenzoyl)-beta-D-talopyranoside, ... (4 entities in total)
• 機能のキーワード: carbohydrates-binding protein, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16301.90

構造登録者

Collins, P.M.,Kishor, C.,Blanchard, H. (登録日: 2021-07-15, 公開日: 2022-07-13, 最終更新日: 2023-10-18)

• 主引用文献: Bum-Erdene, K.,Collins, P.M.,Hugo, M.W.,Tarighat, S.S.,Fei, F.,Kishor, C.,Leffler, H.,Nilsson, U.J.,Groffen, J.,Grice, I.D.,Heisterkamp, N.,Blanchard, H.; Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia.; J.Med.Chem., 65:5975-5989, 2022; PubMed: 35427125; DOI: 10.1021/acs.jmedchem.1c01296

実験手法

X-RAY DIFFRACTION (1.337 Å)