7RD2

Co-crystal structure of Chaetomium glucosidase with compound 2

これはPDB形式変換不可エントリーです。

7RD2 の概要

• エントリーDOI: 10.2210/pdb7rd2/pdb
• 分子名称: Chaetomium alpha glucosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R,3R,4R,5S)-1-{[4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-nitroanilino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine-3,4,5-triol, ... (6 entities in total)
• 機能のキーワード: alpha glucosidase i, hydrolase, inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Thermochaetoides thermophila
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 189342.05

構造登録者

Karade, S.S.,Mariuzza, R.A. (登録日: 2021-07-09, 公開日: 2023-02-22, 最終更新日: 2023-03-01)

• 主引用文献: Karade, S.S.,Franco, E.J.,Rojas, A.C.,Hanrahan, K.C.,Kolesnikov, A.,Yu, W.,MacKerell Jr., A.D.,Hill, D.C.,Weber, D.J.,Brown, A.N.,Treston, A.M.,Mariuzza, R.A.; Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity.; J.Med.Chem., 66:2744-2760, 2023; PubMed: 36762932; DOI: 10.1021/acs.jmedchem.2c01750

実験手法

X-RAY DIFFRACTION (2.61 Å)