7RCZ

Crystal structure of C. difficile SpoVD in complex with ampicillin

7RCZ の概要

• エントリーDOI: 10.2210/pdb7rcz/pdb
• 分子名称: Stage V sporulation protein D (Sporulation specific penicillin-binding protein), SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (8 entities in total)
• 機能のキーワード: peptidoglycan, pbp, pbp2, cell wall, transpeptidase, b-lactam, gram-positive, spore, sporulation, peptide binding protein
• 由来する生物種: Clostridioides difficile (strain R20291) (Peptoclostridium difficile)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123672.96

構造登録者

Sacco, M.,Chen, Y. (登録日: 2021-07-08, 公開日: 2022-03-23, 最終更新日: 2023-10-18)

• 主引用文献: Sacco, M.D.,Wang, S.,Adapa, S.R.,Zhang, X.,Lewandowski, E.M.,Gongora, M.V.,Keramisanou, D.,Atlas, Z.D.,Townsend, J.A.,Gatdula, J.R.,Morgan, R.T.,Hammond, L.R.,Marty, M.T.,Wang, J.,Eswara, P.J.,Gelis, I.,Jiang, R.H.Y.,Sun, X.,Chen, Y.; A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.; Nat Commun, 13:4370-4370, 2022; PubMed: 35902581; DOI: 10.1038/s41467-022-32086-6

実験手法

X-RAY DIFFRACTION (2.2 Å)