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7RCY

Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole

7RCY の概要
エントリーDOI10.2210/pdb7rcy/pdb
分子名称Penicillin-binding protein, (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ZINC ION, ... (4 entities in total)
機能のキーワードpeptidoglycan, pbp, pbp2, cell wall, transpeptidase, b-lactam, gram-positive, spore, sporulation, peptide binding protein
由来する生物種Clostridioides difficile (strain R20291) (Peptoclostridium difficile)
タンパク質・核酸の鎖数1
化学式量合計104582.46
構造登録者
Sacco, M.,Chen, Y. (登録日: 2021-07-08, 公開日: 2022-03-23, 最終更新日: 2023-10-18)
主引用文献Sacco, M.D.,Wang, S.,Adapa, S.R.,Zhang, X.,Lewandowski, E.M.,Gongora, M.V.,Keramisanou, D.,Atlas, Z.D.,Townsend, J.A.,Gatdula, J.R.,Morgan, R.T.,Hammond, L.R.,Marty, M.T.,Wang, J.,Eswara, P.J.,Gelis, I.,Jiang, R.H.Y.,Sun, X.,Chen, Y.
A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun, 13:4370-4370, 2022
Cited by
PubMed: 35902581
DOI: 10.1038/s41467-022-32086-6
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3 Å)
構造検証レポート
Validation report summary of 7rcy
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-07-31に公開中

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