7RBY

Crystal structure of Nanobody nb112 and SARS-CoV-2 RBD

Summary for 7RBY

Entry DOI	10.2210/pdb7rby/pdb
Descriptor	Spike protein S1, Ilama-isolated nanobody NIH-CoV nb-112 specific to SARS-CoV-2 RBD, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	sars-cov-2, nanobody, rbd-specific, broad neutralization, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	4
Total formula weight	75756.73
Authors	Chen, Y.,Tolbert, W.,Pazgier, M. (deposition date: 2021-07-06, release date: 2022-03-23, Last modification date: 2023-10-18)
Primary citation	Esparza, T.J.,Chen, Y.,Martin, N.P.,Bielefeldt-Ohmann, H.,Bowen, R.A.,Tolbert, W.D.,Pazgier, M.,Brody, D.L. Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19. Mabs, 14:2047144-2047144, Cited by PubMed: 35289719 DOI: 10.1080/19420862.2022.2047144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation