7RB1

Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid

7RB1 の概要

• エントリーDOI: 10.2210/pdb7rb1/pdb
• 分子名称: Isocitrate lyase, dihydroxyacetic acid, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: tuberculosis, glyoxylate shunt, inhibitor, lyase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 190231.25

構造登録者

Krieger, I.V.,Mellott, D.,Meek, T.,Sacchettini, J.C. (登録日: 2021-07-05, 公開日: 2021-12-01, 最終更新日: 2023-10-18)

• 主引用文献: Mellott, D.M.,Torres, D.,Krieger, I.V.,Cameron, S.A.,Moghadamchargari, Z.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D.,Harris, L.D.; Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2 R ,3 S )-2-Hydroxy-3-(nitromethyl)succinic acid.; J.Am.Chem.Soc., 143:17666-17676, 2021; PubMed: 34664502; DOI: 10.1021/jacs.1c07970

実験手法

X-RAY DIFFRACTION (1.9 Å)