7RA5

CDK2 IN COMPLEX WITH COMPOUND 4

Summary for 7RA5

Entry DOI	10.2210/pdb7ra5/pdb
Descriptor	Cyclin-dependent kinase 2, 4-[7-(methanesulfonyl)-1H-indol-3-yl]-N-[(3S)-piperidin-3-yl]-5-(trifluoromethyl)pyrimidin-2-amine (3 entities in total)
Functional Keywords	cdk2, cyclin-dependent kinase 2, proteros biostructures gmbh, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34544.08
Authors	Marineau, J.J.,Malojcic, G. (deposition date: 2021-06-30, release date: 2021-11-03, Last modification date: 2024-04-03)
Primary citation	Marineau, J.J.,Hamman, K.B.,Hu, S.,Alnemy, S.,Mihalich, J.,Kabro, A.,Whitmore, K.M.,Winter, D.K.,Roy, S.,Ciblat, S.,Ke, N.,Savinainen, A.,Wilsily, A.,Malojcic, G.,Zahler, R.,Schmidt, D.,Bradley, M.J.,Waters, N.J.,Chuaqui, C. Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. J.Med.Chem., 65:1458-1480, 2022 Cited by PubMed: 34726887 DOI: 10.1021/acs.jmedchem.1c01171 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation