7R9N

Crystal structure of HPK1 in complex with GNE1858

7R9N の概要

• エントリーDOI: 10.2210/pdb7r9n/pdb
• 分子名称: Hematopoietic progenitor kinase, N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: kinase, inhibitor, map4k1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67527.18

構造登録者

Wu, P.,Lehoux, I.,Wang, W. (登録日: 2021-06-29, 公開日: 2022-01-05, 最終更新日: 2023-10-18)

• 主引用文献: Chan, B.K.,Seward, E.,Lainchbury, M.,Brewer, T.F.,An, L.,Blench, T.,Cartwright, M.W.,Chan, G.K.Y.,Choo, E.F.,Drummond, J.,Elliott, R.L.,Gancia, E.,Gazzard, L.,Hu, B.,Jones, G.E.,Luo, X.,Madin, A.,Malhotra, S.,Moffat, J.G.,Pang, J.,Salphati, L.,Sneeringer, C.J.,Stivala, C.E.,Wei, B.,Wang, W.,Wu, P.,Heffron, T.P.; Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).; Acs Med.Chem.Lett., 13:84-91, 2022; PubMed: 35059127; DOI: 10.1021/acsmedchemlett.1c00473

実験手法

X-RAY DIFFRACTION (1.5 Å)