7R8R

Physachenolide C with Bromodomain (BRD3-BD1)

Summary for 7R8R

• Entry DOI: 10.2210/pdb7r8r/pdb
• Related: 3s92
• Descriptor: Bromodomain-containing protein 3, Physachenolide C (3 entities in total)
• Functional Keywords: bromodomain 3, physachenolide c, prostate cancer, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14915.22

Authors

Fromme, R.,Sivinski, J.,Zerio, C.,Gunatilaka, A.A.L.,Chapman, E. (deposition date: 2021-06-27, release date: 2022-09-21, Last modification date: 2023-10-25)

• Primary citation: Zerio, C.J.,Sivinski, J.,Wijeratne, E.M.K.,Xu, Y.M.,Ngo, D.T.,Ambrose, A.J.,Villa-Celis, L.,Ghadirian, N.,Clarkson, M.W.,Zhang, D.D.,Horton, N.C.,Gunatilaka, A.A.L.,Fromme, R.,Chapman, E.; Physachenolide C is a Potent, Selective BET Inhibitor.; J.Med.Chem., 66:913-933, 2023; PubMed: 36577036; DOI: 10.1021/acs.jmedchem.2c01770

Experimental method

X-RAY DIFFRACTION (1.8 Å)