7R8L

Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody C099 and CR3022

7R8L の概要

• エントリーDOI: 10.2210/pdb7r8l/pdb
• 分子名称: C099 Fab Heavy Chain, C099 Fab Light Chain, Spike protein S1, ... (7 entities in total)
• 機能のキーワード: sars-cov-2, receptor binding domain, rbd, neutralizing antibody, covid-19, spike, antiviral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 116442.97

構造登録者

Barnes, C.O.,Bjorkman, P.J. (登録日: 2021-06-26, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Muecksch, F.,Weisblum, Y.,Barnes, C.O.,Schmidt, F.,Schaefer-Babajew, D.,Wang, Z.,C Lorenzi, J.C.,Flyak, A.I.,DeLaitsch, A.T.,Huey-Tubman, K.E.,Hou, S.,Schiffer, C.A.,Gaebler, C.,Da Silva, J.,Poston, D.,Finkin, S.,Cho, A.,Cipolla, M.,Oliveira, T.Y.,Millard, K.G.,Ramos, V.,Gazumyan, A.,Rutkowska, M.,Caskey, M.,Nussenzweig, M.C.,Bjorkman, P.J.,Hatziioannou, T.,Bieniasz, P.D.; Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.; Immunity, 54:1853-1868.e7, 2021; PubMed: 34331873; DOI: 10.1016/j.immuni.2021.07.008

実験手法

X-RAY DIFFRACTION (2.6 Å)