7R62
Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative
Summary for 7R62
Entry DOI | 10.2210/pdb7r62/pdb |
Descriptor | Estrogen receptor, 11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7beta-yl]-N-methyl-N-propylundecanamide (3 entities in total) |
Functional Keywords | breast cancer, selective estrogen receptor degrader, alpha helical bundle, antiestrogen, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 28866.99 |
Authors | Diennet, M.,El Ezzy, M.,Thiombane, K.,Cotnoir-White, D.,Poupart, J.,Gao, Z.,Mendoza Sanchez, R.,Marinier, A.,Gleason, J.,Greene, G.L.,Mader, S.C.,Fanning, S.W. (deposition date: 2021-06-22, release date: 2022-07-06, Last modification date: 2023-10-18) |
Primary citation | Fanning, S.W. Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Desmethyl ICI164,384 Derivative To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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