7R3U
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
Summary for 7R3U
Entry DOI | 10.2210/pdb7r3u/pdb |
Related | 7QKE 7QNN 7QWN 7R1I |
Descriptor | Steroid C26-monooxygenase, 1-[4-(1,2,3-thiadiazol-4-yl)phenyl]methanamine, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | cyp, p450, cytochrome, cholesterol, tuberculosis, inhibitor, fragment, enzyme, cyp125, oxidoreductase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 3 |
Total formula weight | 143323.68 |
Authors | Snee, M.,Katariya, M.,Leys, D.,Levy, C. (deposition date: 2022-02-07, release date: 2023-02-22, Last modification date: 2024-02-07) |
Primary citation | Katariya, M.M.,Snee, M.,Tunnicliffe, R.B.,Kavanagh, M.E.,Boshoff, H.I.M.,Amadi, C.N.,Levy, C.W.,Munro, A.W.,Abell, C.,Leys, D.,Coyne, A.G.,McLean, K.J. Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29:e202203868-e202203868, 2023 Cited by PubMed: 36912255DOI: 10.1002/chem.202203868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
Download full validation report