7R3I

PROSS optimitzed variant of RhlR (61 mutations) in complex with the synthetic antagonist mBTL

7R3I の概要

• エントリーDOI: 10.2210/pdb7r3i/pdb
• 分子名称: PROSS optimized variant of RhlR with 61 mutations, 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide (2 entities in total)
• 機能のキーワード: quorum sensing, luxr-type transcriptional regulator, pseudomonas, dna binding protein, gene regulation, mbtl, rhamnolipid, transcription
• 由来する生物種: Pseudomonas aeruginosa PAO1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56189.19

構造登録者

Henke, S.,Blankenfeldt, W. (登録日: 2022-02-07, 公開日: 2022-12-14, 最終更新日: 2024-05-01)

• 主引用文献: Borgert, S.R.,Henke, S.,Witzgall, F.,Schmelz, S.,Zur Lage, S.,Hotop, S.K.,Stephen, S.,Lubken, D.,Kruger, J.,Gomez, N.O.,van Ham, M.,Jansch, L.,Kalesse, M.,Pich, A.,Bronstrup, M.,Haussler, S.,Blankenfeldt, W.; Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.; Nat Commun, 13:7402-7402, 2022; PubMed: 36456567; DOI: 10.1038/s41467-022-35030-w

実験手法

X-RAY DIFFRACTION (3.1 Å)