7R38

Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pyrococcus furiosus in complex with S-inosyl-L-homocysteine

Summary for 7R38

• Entry DOI: 10.2210/pdb7r38/pdb
• Related: 7R37
• Descriptor: Adenosylhomocysteinase, (2S)-2-AMINO-4-({[(2S,3S,4R,5R)-3,4-DIHYDROXY-5-(6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)TETRAHYDROFURAN-2-YL]METHYL}THIO)BUTANOIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: complex, s-adenosyl-l-homocysteine (sah), s-adenosyl-l-methionine (sam), hydrolase
• Biological source: Pyrococcus furiosus
• Total number of polymer chains: 2
• Total formula weight: 101338.16

Authors

Saleem-Batcha, R.,Popadic, D.,Andexer, J.N. (deposition date: 2022-02-06, release date: 2023-02-15, Last modification date: 2024-09-18)

• Primary citation: Koeppl, L.H.,Popadic, D.,Saleem-Batcha, R.,Germer, P.,Andexer, J.N.; Structure, function and substrate preferences of archaeal S-adenosyl-L-homocysteine hydrolases.; Commun Biol, 7:380-380, 2024; PubMed: 38548921; DOI: 10.1038/s42003-024-06078-9

Experimental method

X-RAY DIFFRACTION (2.05 Å)