7R2B

PI3Kdelta in complex with an inhibitor

7R2B の概要

• エントリーDOI: 10.2210/pdb7r2b/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, (4~{S})-3-[6-[2-azanyl-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-yl-pyrimidin-4-yl]-4-methyl-1,3-oxazolidin-2-one (3 entities in total)
• 機能のキーワード: kinase, complex, inhibitor, hydrolase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108249.03

構造登録者

Gutmann, S.,Rummel, G.,Shrestha, B. (登録日: 2022-02-04, 公開日: 2022-05-18, 最終更新日: 2024-01-31)

• 主引用文献: Fairhurst, R.A.,Furet, P.,Imbach-Weese, P.,Stauffer, F.,Rueeger, H.,McCarthy, C.,Ripoche, S.,Oswald, S.,Arnaud, B.,Jary, A.,Maira, M.,Schnell, C.,Guthy, D.A.,Wartmann, M.,Kiffe, M.,Desrayaud, S.,Blasco, F.,Widmer, T.,Seiler, F.,Gutmann, S.,Knapp, M.,Caravatti, G.; Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.; J.Med.Chem., 65:8345-8379, 2022; PubMed: 35500094; DOI: 10.1021/acs.jmedchem.2c00267

実験手法

X-RAY DIFFRACTION (2.7 Å)