7R26
PI3K delta in complex with SD5
Summary for 7R26
Entry DOI | 10.2210/pdb7r26/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine (3 entities in total) |
Functional Keywords | kinase, inhibitor, complex, hydrolase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 1 |
Total formula weight | 108234.06 |
Authors | Gutmann, S.,Rummel, G.,Shrestha, B. (deposition date: 2022-02-04, release date: 2022-05-18, Last modification date: 2024-01-31) |
Primary citation | Fairhurst, R.A.,Furet, P.,Imbach-Weese, P.,Stauffer, F.,Rueeger, H.,McCarthy, C.,Ripoche, S.,Oswald, S.,Arnaud, B.,Jary, A.,Maira, M.,Schnell, C.,Guthy, D.A.,Wartmann, M.,Kiffe, M.,Desrayaud, S.,Blasco, F.,Widmer, T.,Seiler, F.,Gutmann, S.,Knapp, M.,Caravatti, G. Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor. J.Med.Chem., 65:8345-8379, 2022 Cited by PubMed: 35500094DOI: 10.1021/acs.jmedchem.2c00267 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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