7R1P
X-ray structure of the adduct formed upon reaction of the gold(I) N-heterocyclic carbene complex Au1 with RNase A
This is a non-PDB format compatible entry.
Summary for 7R1P
Entry DOI | 10.2210/pdb7r1p/pdb |
Descriptor | Ribonuclease pancreatic, GOLD ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | metallodrug, protein-metal interaction, gold, carbene, anticancer, rna binding protein |
Biological source | Bos taurus (cattle) |
Total number of polymer chains | 2 |
Total formula weight | 27906.65 |
Authors | Merlino, A.,Ferraro, G. (deposition date: 2022-02-03, release date: 2022-07-13, Last modification date: 2024-01-31) |
Primary citation | Annunziata, A.,Ferraro, G.,Cucciolito, M.E.,Imbimbo, P.,Tuzi, A.,Monti, D.M.,Merlino, A.,Ruffo, F. Halo complexes of gold(I) containing glycoconjugate carbene ligands: synthesis, characterization, cytotoxicity and interaction with proteins and DNA model systems. Dalton Trans, 51:10475-10485, 2022 Cited by PubMed: 35766118DOI: 10.1039/d2dt00423b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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